Imperfect osteogenesis treatment

Imperfect osteogenesis is a congenital malformation of bone tissue, which is manifested by increased brittleness and brittle bones. Vice is extremely rare. 10-15% of all cases of the disease is hereditary.

Imperfect osteogenesis has two forms:

  • early form, or Frolik's disease is characterized by the fact that multiple fractures occur already in utero or in the first days after birth;

  • late form, or Lobschein's disease, or idiopathic osteopsychyrosis, when fractures appear later - after 1 year of the child's life.


  • Pathogenesis and etiology of imperfect osteogenesis are still unclear. In patients, bone growth is seen to be wide in violation of normal growth in length.

    Treatment

    Treatment of imperfect osteogenesis focuses on symptomatic therapies, as the disease is genetic.

    The treatment methods are as follows: physiotherapy, osteosynthesis with pin, conservative treatment, Bisphosphonate therapy, surgical treatment.

    Conservative treatment includes the use of highly effective modern medications. With imperfect osteogenesis, the use of Ergocalciferol, complexones, calcium gluconate, bisphosphonates, glycerophosphate, and also potassium and magnesium salts and vitamin D is practiced. As an additional treatment, growth hormone is used.

    Operative surgical treatment consists in the immobilization of fractures with various metal structures together with bone plastic, and also in the installation of transits of the "fagots" type. In order to prevent further progress of deformation due to inadequate axial loads, a complete restoration of the axis of the segment is necessary. In some cases, repeated operations are required due to the fact that as the bones grow, it is necessary to replace the inserted pins.

    In case of fractures, gypsum longes should be applied.

    In addition, it is necessary to conduct rehabilitation courses and psychotherapeutic treatment. It is very important to teach the child and his parents the right behavior and ways of adapting to the way of life in order to avoid further situations provoking fracture.

    Currently, there are clinics that use for the treatment of fractures flexible titanium rods, which have hypoallergenic properties and provide a stable fixation of the fracture. This, in turn, allows you to abandon the immobilization with a plaster bandage, making it difficult to care for.