Fungi of the genus Candida are representatives of the normal microflora of the vagina, but they can also enter the genital tract of a woman from the intestine, by direct contact with an endogenous source of infection (sick or carriers) through infected objects or sexually. Their pathogenic properties they can exhibit with a decrease in the body's defenses, hormonal disorders (for example - diabetes), metabolic imbalance, dysbiosis, as a result of taking antibiotics, corticosteroids, immunosuppressants, against oral contraception.
Candida colpitis is characterized by a prolonged course, deep penetration of fungi into the vaginal epithelium is bug-intensive with a lesion involving the mucosal inflammatory process of the pihvinnoi part of the cervix and endocervix.
There are acute (duration of up to 2 months) and chronic (duration of more than 2 months) form of candidiasis. The acute form is characterized by profuse liquid discharges with an admixture of cheese-like inclusions and an acidic unpleasant odor, also a constant intolerable itching of the vulva, intensified in the afternoon, at night or before menstruation, and vaginal heartburn. When examining the mucosa, its hyperemia, grayish-white coatings are noted, which are very difficult to separate.
In chronic form, the above symptoms are clearly pronounced. The mucous membrane can be non-permeable and the attacks from it can be easily removed.
Treatment of candidiasis
Treatment of patients should be comprehensive and based on the principles of course therapy, which includes the use of specific and nonspecific drugs.
To non-specific drugs include the local use of tetraborate in glycerol, gentian violet (prevents the attachment of fungi).
Specific antimycotic drugs destroy the mycelium and cells of the fungi themselves. These include:
- Nystatin administered intravenously to 1000000 units 4 times a day for 14-16 days;
- Pimafucin (natamycin) - 0.1 g vaginal tablets once a day at night for 3-6dib;
- Ketoconazole (Nizoral) - inside 0.2 g in tablets 2 times a day during meals for 5 days.
Local therapy consists in that first it is necessary to carry out mechanical cleaning of the vagina in order to remove from it the secretions and the products of vital activity of microorganisms with the help of a cotton swab or with the help of douching. Then applied to the walls and vaults of the vagina, the cervix of the antimycotic ointment (mebetizolova, clotrimazolova, etc.) 2 times a day. It is desirable that the sexual partner undergo a course of therapy (Nizoral 200 mg 2 times a day for 5-7 days).
In chronic candidiasis, the course of therapy is about 7 days with 3 subsequent menstrual periods, a 10 - day course of lactobacterin for 5 doses intravaginally.