It is determined that progesterone, in addition to everything, normalizes the state of the immune response in the early stages of pregnancy. Indeed, with the normal course of pregnancy, the yellow body, and then the placenta, produce the necessary and sufficient amount of progesterone. It affects the activated lymphocytes, which produce a special protein - progesterone-induced blocking factor (PIBF). This protein has an anti-abortive effect.
With the preservation of pregnancy and with luteal insufficiency, primary placental insufficiency may also form. To prevent this, a full preparation for pregnancy and constant medical supervision for women with a habitual and threatening miscarriage are needed.
Instructions for the use of Dufaston
This state can be effectively overcome by direct action on the progesterone receptors, which is accomplished by replenishment of the endogenous progesterone deficiency. This is done with the use of medications - progestogens. Dyufaston is a modern and effective gestagenic agent. Duphaston (dydrogesterone), without difficulty, is absorbed when used. Dydrogesterone causes a full phase of secretion in the endometrium, which ensures its high ability to maintain pregnancy.
Duphaston is a potent progestogen, close in structure to the progesterone produced by the woman's body, it has a high affinity for the receptors of progesterone.
It differs from other progestogens in that it is not a derivative of testosterone, and is completely different from most of the synthetic progestogens. This allows you not to allow side effects, typical for most of these funds.
How does Dyufaston work when there is a threat of miscarriage?
The special chemical structure of dydrogesterone provides its enhanced bioavailability after oral administration and the absence of metabolites with estrogenic or androgenic activity.
Studies show that the anti-abortion effect of progesterone during early pregnancy is also provided by the maternal immune response. The protein synthesized by lymphocytes in the presence of Dufaston prevents reactions of trophoblast rejection. In addition, Dyufaston in the threat of miscarriage also has the ability to relax the muscles of the uterus.
Duphaston is free from such drawbacks of synthetic progestogens as feminization of the fetus male. It shows no side effects on liver function and blood coagulability, does not provoke coarsening of voice, acne, hirsutism and masculinization of the reproductive organs of the female fetus, has no metabolic effects. When it is used, it does not change the activity of the pituitary-ovarian system and adrenocortical atrophy does not occur.
Composition and application
With a threatening miscarriage, the treatment includes consuming forty milligrams of the drug at a time, then ten milligrams every eight hours until the signs of abortion disappear. With the usual miscarriage, ten milligrams of Duphaston are taken twice a day until the eighteenth to twentieth week of pregnancy.
In other words, Dufaston is a hormone therapy that is used to correct a number of pathological conditions that are associated with progesterone deficiency.
Duphaston has some contraindications, including renal failure, epilepsy, Rotor or Dabin-Johnson syndromes, migraine, cardiovascular disease and hypersensitivity to the components of the drug.